DRUG AND NOVEL SUBSTITUTED LACTAM HAVING ERYTHROCYTE AND PLATELET ANTI-COAGULATION ACTION

Novel medicaments containing lactams of the formula I in which R represents a hydrogen atom, an alkyl or cycloalkyl group, R denotes a hydrogen atom, an alkyl, alkenyl or a cycloalkyl group, R denotes an alkyl, alkenyl or cyano group, or a carbonyl group substituted by a hydroxyl, alkyl, alkoxy, amino, alkylamino, dialkylamino or hydrazino group, or R and R together represent an alkylidene or cycloalkylidene group, or R and R , together with the carbon atom to which they are bonded, form a spirocycle, n can be equal to 0 or 1, A in the substituents R -X-A- represents the groups R -X-CO-NH-, R -X-NH-CO-NH- or R -X-O-CO-NH- in which X represents a valence line, an alkylene chain or the vinyl group, R denotes a mono- or polysubstituted phenyl ring, or a heterocyclic 5-membered ring having 1-4 hetero atoms, or a pyrazine, pyridazine, oxazine, thiazine, triazine or tetrazine ring or quinoline radical, or in the case in which X represents a bond, R , besides the radicals mentioned, also denotes a C2-C12-alkyl or formylaminoalkyl group, their tautomers and their physiologically tolerable salts, and also novel lactams of the general formula I, process for their preparation and medicaments containing them for the treatment of diseases in which erythrocyte and platelet aggregation play an important role.