DIUREA COMPOUND AND PRODUCTION THEREOF

NEW MATERIAL:A compound expressed by formula I [R -R are (substituted) phenyl and phenyl lower alkyl (substituent group is halogen, lower alkyl or lower alkoxy)furyl or furyl-lower alkyl; n is 1-10] or salt thereof. EXAMPLE:1,7-Bis[3-(2,4-difluorophenyl)-1-furfurylureido]heptane. USE:A preventive an...

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Hauptverfasser: ITO TOKUKI, YASUNAGA TOMOYUKI, IIIZUMI YUICHI
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creator ITO TOKUKI
YASUNAGA TOMOYUKI
IIIZUMI YUICHI
description NEW MATERIAL:A compound expressed by formula I [R -R are (substituted) phenyl and phenyl lower alkyl (substituent group is halogen, lower alkyl or lower alkoxy)furyl or furyl-lower alkyl; n is 1-10] or salt thereof. EXAMPLE:1,7-Bis[3-(2,4-difluorophenyl)-1-furfurylureido]heptane. USE:A preventive and treating agent for cerebral infarction, transient ischemic paroxym, angina pectoris, peripheral thrombosis and obstruction, etc. PREPARATION:A diamine derivative expressed by formula II is reacted with an isocyanate compound expressed by formula III [R and R are (substituted) phenyl and phenyl lower alkyl (substituent group is halogen, lower alkyl, etc.) in a molar amount of normally twice - excess based on the diamine derivative according to the reaction formula to afford the aimed compound expressed by formula I or salt thereof.
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EXAMPLE:1,7-Bis[3-(2,4-difluorophenyl)-1-furfurylureido]heptane. USE:A preventive and treating agent for cerebral infarction, transient ischemic paroxym, angina pectoris, peripheral thrombosis and obstruction, etc. PREPARATION:A diamine derivative expressed by formula II is reacted with an isocyanate compound expressed by formula III [R and R are (substituted) phenyl and phenyl lower alkyl (substituent group is halogen, lower alkyl, etc.) in a molar amount of normally twice - excess based on the diamine derivative according to the reaction formula to afford the aimed compound expressed by formula I or salt thereof.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19890816&amp;DB=EPODOC&amp;CC=JP&amp;NR=H01203360A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19890816&amp;DB=EPODOC&amp;CC=JP&amp;NR=H01203360A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ITO TOKUKI</creatorcontrib><creatorcontrib>YASUNAGA TOMOYUKI</creatorcontrib><creatorcontrib>IIIZUMI YUICHI</creatorcontrib><title>DIUREA COMPOUND AND PRODUCTION THEREOF</title><description>NEW MATERIAL:A compound expressed by formula I [R -R are (substituted) phenyl and phenyl lower alkyl (substituent group is halogen, lower alkyl or lower alkoxy)furyl or furyl-lower alkyl; n is 1-10] or salt thereof. 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EXAMPLE:1,7-Bis[3-(2,4-difluorophenyl)-1-furfurylureido]heptane. USE:A preventive and treating agent for cerebral infarction, transient ischemic paroxym, angina pectoris, peripheral thrombosis and obstruction, etc. PREPARATION:A diamine derivative expressed by formula II is reacted with an isocyanate compound expressed by formula III [R and R are (substituted) phenyl and phenyl lower alkyl (substituent group is halogen, lower alkyl, etc.) in a molar amount of normally twice - excess based on the diamine derivative according to the reaction formula to afford the aimed compound expressed by formula I or salt thereof.</abstract><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title DIUREA COMPOUND AND PRODUCTION THEREOF
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