PREDETERMINED OF OPTICALLY ACTIVE 3-DEMETHYLMEVALONNIC ACID DERIVATIVE

PREDETERMINED OF OPTICALLY ACTIVE 3-DEMETHYLMEVALONNIC ACID DERIVATIVE

A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I I (3,5-dihydroxy carboxylic acid derivatives) or of the formula II II ( beta -hydroxy la...

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Bibliographische Detailangaben
Hauptverfasser: KURUTO KESERAA, GEERUHARUTO BETSUKU, EKEHARUTO BAADAA, GIYUNTAA BUESU
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I I (3,5-dihydroxy carboxylic acid derivatives) or of the formula II II ( beta -hydroxy lactones) in which R, R1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII XII in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.