ORGAN AND COMPOSITION FOR PREVENTING ADHESION AT PART OF ORGAN

PURPOSE: To obtain the subject composition containing a water-based hydrogel containing hydroxyethyl cellulose as a base and t-PA or rt-PA and capable of almost completely inhibiting the formation of adhesion only by single application after the surgical intervention or inflammatory stimulation. CONSTITUTION: t-PA or rt-PA is dissolved at a concentration of 0.05-50 mg/ml, preferably 0.3-10mg/mL in a water-based hydrogel containing 1-3wt.% of a hydroxyethyl cellulose (preferably having an average molecular substitution level of 1.5-3.0 hydroxyethyl groups per 1 unit of anhydrous glucose). The hydroxyethyl cellulose hydrocgel has adhesion inhibiting effect by itself, however, the activity is increased by the presence of t-PA. Preferably, a sterilized hydrogel and freeze-dried t-PA or rt-PA are stored in separate containers and are mixed with each other immediately before use to prepare a solution.