ANTIMICROBIAL AGENT FOR MARINE

NEW MATERIAL:A compound (salt) expressed by formula I [X is lower alkylamino or alicyclic amino expressed by formula II (Y is H or lower alkyl; Z is methylene, methine, O, S, etc.; R1 is lower alkyl, OH, etc.; m and n are integers of 1-3); R is H or lower alkyl]. EXAMPLE:9-Fluoro-2,3-dihydro-3-methy...

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Hauptverfasser: YOSHIOKA TOSHIYUKI, ITAHANA HIDENOBU, INOUE SHINICHI, TAKEI MASAKAZU, TAKAHATA TOSHIHIRO
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creator YOSHIOKA TOSHIYUKI
ITAHANA HIDENOBU
INOUE SHINICHI
TAKEI MASAKAZU
TAKAHATA TOSHIHIRO
description NEW MATERIAL:A compound (salt) expressed by formula I [X is lower alkylamino or alicyclic amino expressed by formula II (Y is H or lower alkyl; Z is methylene, methine, O, S, etc.; R1 is lower alkyl, OH, etc.; m and n are integers of 1-3); R is H or lower alkyl]. EXAMPLE:9-Fluoro-2,3-dihydro-3-methyl-10-(4-ethyl-1-piperazinyl)-7-oxo -7H- pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hydrochloride hemihydrate. USE:A remedy for infectious disease of fishes and shellfishes. PREPARATION:For example, 9-fluoro-2,3-dihydro-3-methyl-10-(4-ethyl-1- piperazinyl)-7-oxo-7H-pyrido [1,2,3-de][1,4]henzoxazine-6-carboxylic acid and concentrated hydrochloric acid added into ethanol are reacted to provide the compound expressed by formula I which is a hydrochloride salt hemihydrate thereof.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ANTIMICROBIAL AGENT FOR MARINE
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