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NEW MATERIAL:A compound (salt) expressed by formula I [X is lower alkylamino or alicyclic amino expressed by formula II (Y is H or lower alkyl; Z is methylene, methine, O, S, etc.; R1 is lower alkyl, OH, etc.; m and n are integers of 1-3); R is H or lower alkyl]. EXAMPLE:9-Fluoro-2,3-dihydro-3-methy...

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Bibliographische Detailangaben
Hauptverfasser:	YOSHIOKA TOSHIYUKI, ITAHANA HIDENOBU, INOUE SHINICHI, TAKEI MASAKAZU, TAKAHATA TOSHIHIRO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound (salt) expressed by formula I [X is lower alkylamino or alicyclic amino expressed by formula II (Y is H or lower alkyl; Z is methylene, methine, O, S, etc.; R1 is lower alkyl, OH, etc.; m and n are integers of 1-3); R is H or lower alkyl]. EXAMPLE:9-Fluoro-2,3-dihydro-3-methyl-10-(4-ethyl-1-piperazinyl)-7-oxo -7H- pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hydrochloride hemihydrate. USE:A remedy for infectious disease of fishes and shellfishes. PREPARATION:For example, 9-fluoro-2,3-dihydro-3-methyl-10-(4-ethyl-1- piperazinyl)-7-oxo-7H-pyrido [1,2,3-de][1,4]henzoxazine-6-carboxylic acid and concentrated hydrochloric acid added into ethanol are reacted to provide the compound expressed by formula I which is a hydrochloride salt hemihydrate thereof.