CYSTEINE PROTEINASE INHIBITOR

NEW MATERIAL:A compound shown by formula I (R1 is benzyloxycarbonyl or 4-phenylbutyryl; R2 is isopropyl or isobutyl; R3 is butyl, benzyl or methylthioethyl; R4 is H or chloromethyl). EXAMPLE:N-Benzyloxycarbonyl-L-leucyl-L-phenylalaninal. USE:A cysteine proteinase inhibitor showing strongly inhibitor...

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Bibliographische Detailangaben
Hauptverfasser:	SAITO MASAYUKI, HIGUCHI NAOKI, IWAZAWA RITSUO, TSUNODA MOTOO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound shown by formula I (R1 is benzyloxycarbonyl or 4-phenylbutyryl; R2 is isopropyl or isobutyl; R3 is butyl, benzyl or methylthioethyl; R4 is H or chloromethyl). EXAMPLE:N-Benzyloxycarbonyl-L-leucyl-L-phenylalaninal. USE:A cysteine proteinase inhibitor showing strongly inhibitory activity against enzymes, especially papain and calpain, useful as an anti-inflammatory drug and remedy for muscular dystrophy and cataract. PREPARATION:A compound shown by formula II (R5 is lower alkyl) is reduced with a reducing agent in an organic solvent to an alcohol compound and further oxidized with an oxidizing agent into an aldehyde to give a compound shown by formula I (in the case where R4 is H).