CYTORHODIN S DERIVATIVE, PRODUCTION THEREOF AND ANTICANCER DRUG CONTAINING SAID DERIVATIVE

CYTORHODIN S DERIVATIVE, PRODUCTION THEREOF AND ANTICANCER DRUG CONTAINING SAID DERIVATIVE

NEW MATERIAL:A cytorhodin derivative shown by formula I [X is -NH2, -NH-R -NH2, -NH-R -COOH, -NH-R'-SH, group shown by formula II, formula III or formula IV (R is bifunctional hydrocarbon group which may be replaced with arbitrary substituent group; R is bifunctional hydrocarbon group; R is bif...

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Hauptverfasser: IWAHASHI TOSHIRO, HANSU GERUTO BERUSHIYAITO, SUGAWARA ISAMU, TONE YUKIKO, USUI JUNKO, NUMATA JINKO, OKAZAKI HIROSHI, WATABE HIROSHI, KITAGAWA HIROSHI, KUROBA ITSUO, OKOCHI ETSUKO, SENDA SHUNJI, FUKUDA AKIO, MATSUO AKIHIKO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:NEW MATERIAL:A cytorhodin derivative shown by formula I [X is -NH2, -NH-R -NH2, -NH-R -COOH, -NH-R'-SH, group shown by formula II, formula III or formula IV (R is bifunctional hydrocarbon group which may be replaced with arbitrary substituent group; R is bifunctional hydrocarbon group; R is bifunctional organic group; IgG is immunoglobulin residue; n is 1-15)] or a salt thereof. USE:Selectively acting on cancerous cells and useful as an anticancer drug. Being pharmaceutically manufactured by using an ordinary excipient and additive. Capable of being administered to the vein, the abdominal cavity and the rectum. Applicable by intravenous drip. PREPARATION:Cytorhodin S shown by formula V is reduced with an alkali metal cyanoborohydride in the presence of an ammonium salt or a compound shown by the formula NH2-R'-NH2 to give a compound wherein X is -NH2 or -NH-R -NH2 among compounds shown by formula I.