JP2939280B

NEW MATERIAL:Compounds shown by formula I to formula III {R is alkyl, alkenyl, phenyl which may be replaced, etc.; R is H or NH2; R F-substituted methoxy; R is alkyl, cycloalkyl, phenyl which may be replaced, etc.; X is group shown by formula IV (R is H, OH, NH2, aralkyl or alkyl which may be replaced; R is H or alkyl which may be replaced; A is ethylene, trimethylene, etc.; m is 1 or 2), group shown by formula V [W is OH, alkoxy, etc.; R is H, OH, etc.; B is (CH2)1-4; n is 1 or 2], etc.; Y is 1-5C alkylene which may be replaced; Z is O or S}. EXAMPLE:6-Fluoro-8-difluoromethoxy-1-(4-fluorophenyl)-7-(1-piperazinyl )-1,4- dihydro-4-oxoquinolinecarboxylic acid. USE:An antimicrobial agent. PREPARATION:For example, a compound shown by formula VI is reacted with an amine compound shown by the formula X-H to give a compound shown by formula I.