JP2771494B

The present invention relates to a transgenic nonhuman animal deficient in T-cells, which is provided by fusing heat shock protein (Hsp) gene with a promoter of a gene expressed in thymus and transferring it to an animal. A transgenic nonhuman animal with a shrunken thymus and a deficiency in mature...

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Hauptverfasser: BOKU JUYO, KIN JUNKI, JO TEISUN
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to a transgenic nonhuman animal deficient in T-cells, which is provided by fusing heat shock protein (Hsp) gene with a promoter of a gene expressed in thymus and transferring it to an animal. A transgenic nonhuman animal with a shrunken thymus and a deficiency in mature T-cells can be obtained. This invention is useful for the fields of research of autoimmune disease genesis mechanisms, immune inhibitors and novel drugs.