COMBINATION OF LINAGLIPTIN AND METFORMIN

To provide efficacious, safe and tolerable antidiabetic therapies for diabetic patients who have not previously been treated with an antidiabetic drug and particularly for patients with advanced or late stage type 2 diabetes mellitus, including patients with inadequate glycemic control on convention...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	THOMAS MEINICKE, MAXIMILIAN VON EYNATTEN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide efficacious, safe and tolerable antidiabetic therapies for diabetic patients who have not previously been treated with an antidiabetic drug and particularly for patients with advanced or late stage type 2 diabetes mellitus, including patients with inadequate glycemic control on conventional oral and/or non-oral antidiabetic drugs, such as metformin, sulfonylureas, thiazolidinediones, glinides and/or α-glucosidase inhibitors, and/or GLP-1 or GLP-1 analogues, and/or insulin or insulin analogues, and patients with (chronic) renal disease, renal dysfunction or renal impairment.SOLUTION: The present invention relates to combination of linagliptin and metformin for use in treating a metabolic disease in a patient having chronic kidney disease (CKD).SELECTED DRAWING: None 【課題】以前に抗糖尿病薬によって処置されていない糖尿病患者、特に従来の経口および／または非経口抗糖尿病薬、例えば、メトホルミン、スルホニルウレア、チアゾリジンジオン、グリニド、および／またはα－グルコシダーゼ阻害剤、および／またはＧＬＰ－１もしくはＧＬＰ－１類似体、および／またはインスリンもしくはインスリン類似体による血糖コントロールが不十分な患者を含む、進展期または後期２型糖尿病を有する患者や、（慢性）腎疾患、腎機能不全、または腎障害を有する患者に効果的、安全、および耐用性の抗糖尿病療法を提供する【解決手段】本発明は、慢性腎臓病（ＣＫＤ）を有する患者における代謝性疾患の処置での使用のためのリナグリプチンのメトホルミンとの併用に関する。【選択図】なし