THIOPHENE DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL APPLICATIONS THEREOF

To provide a compound with a thiophene skeleton that inhibits HGK kinase activity and demonstrates therapeutic or preventive effects on motor neuron diseases, such as amyotrophic lateral sclerosis.SOLUTION: The present invention provides a thiophene derivative represented by the formula below, or a...

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Bibliographische Detailangaben
Hauptverfasser:	ARAI TADAMASA, YAGI RYOTARO, TAKEYAMA EMI, SAWAKE HAJIME, TANAKA MASAMICHI, HATTORI HARUHIKO, GOTO YASUFUMI, OSUMI KAZUYA, OGAWA MIZUE, NISHIMURA KAZUMI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide a compound with a thiophene skeleton that inhibits HGK kinase activity and demonstrates therapeutic or preventive effects on motor neuron diseases, such as amyotrophic lateral sclerosis.SOLUTION: The present invention provides a thiophene derivative represented by the formula below, or a pharmacologically acceptable salt thereof.SELECTED DRAWING: None 【課題】本発明は、ＨＧＫのキナーゼ活性を阻害し、筋萎縮性側索硬化症等の運動ニューロン疾患に対して治療又は予防効果を発揮するチオフェン骨格を有する化合物を提供することを目的としている。【解決手段】本発明は、下式に代表されるチオフェン誘導体又はその薬理学的に許容される塩を提供する。TIFF2024108241000171.tif35170【選択図】なし