IN VITRO EXPANSION METHOD OF HAIR FOLLICLE EPITHELIAL STEM CELLS

To provide means for efficiently growing epithelial cells that can be used to produce regenerated hair follicle primordia.SOLUTION: Provided are a culture medium for growing epithelial cells that can be used to produce regenerated hair follicle primordia, comprising a basal medium and at least one o...

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Bibliographische Detailangaben
Hauptverfasser:	TSUJI TAKASHI, TOYOSHIMA KIMIE, OGAWA MIHO, ASAKAWA KYOSUKE, KISHIMOTO KYOSUKE, MORI HISASHI, TAKEO MAKOTO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide means for efficiently growing epithelial cells that can be used to produce regenerated hair follicle primordia.SOLUTION: Provided are a culture medium for growing epithelial cells that can be used to produce regenerated hair follicle primordia, comprising a basal medium and at least one of the following (1) to (3): (1) at least one BMP inhibitor; (2) at least one fibroblast growth factor; and (3) sonic hedgehog (SHH) or a SHH agonist, and a method for growing the epithelial cells using the culture medium.SELECTED DRAWING: None 【課題】再生毛包原基の製造に使用することが可能な上皮性細胞を効率よく増殖するための手段を提供すること。【解決手段】再生毛包原基の製造に使用することが可能な上皮性細胞を増殖するための培養培地であって、基礎培地と、少なくとも以下の（１）～（３）：（１）少なくとも１種のＢＭＰ阻害剤；（２）少なくとも１種の線維芽細胞増殖因子；および（３）ソニックヘッジホッグ（ＳＨＨ）またはＳＨＨアゴニスト、の少なくとも１種とを含む培養培地、および前記培養培地を用いた、前記上皮性細胞を増殖する方法が提供される。【選択図】なし