FGFR3 INHIBITOR COMPOUNDS

FGFR3 INHIBITOR COMPOUNDS

To provide compounds and the like for use in the treatment of systemic sclerosis, fibrosis (e.g. pulmonary fibrosis), achondroplasia, thanatophoric dysplasia (e.g. type I), severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), muenke syndrome or cancer.SOLUTION: The prese...

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Hauptverfasser: DESTA DORO BUME, TIMOTHY SCOTT KERCHER, ANDREW KARL DILGER, KEVIN RONALD CONDROSKI, SHANE MICHAEL WALLS, KAVERI BALAN URKALAN, ANDREW TERRANCE METCALF, ADEDOYIN DAVID ABRAHAM, ROBERT ALAN HAZLITT
Format: Patent
Sprache:eng ; jpn
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:To provide compounds and the like for use in the treatment of systemic sclerosis, fibrosis (e.g. pulmonary fibrosis), achondroplasia, thanatophoric dysplasia (e.g. type I), severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN), muenke syndrome or cancer.SOLUTION: The present invention provides compounds of the formula below, or a pharmaceutically acceptable salt thereof (A: pyrazole, triazole or the like, substituted with R1 and R1A. X1, X2: N, C. X3: N, CH. X4: N, CR9. Y: NH, O, S, bond. Y1: bond, CHR7 or the like. Y2: bond, CHR3 or the like. Y3: CR4R5, CF2. Y4: CR3R4, CF2. Z: bond, CR4R4A or the like. Z1: bond, CH2, CH2CH2).SELECTED DRAWING: None 【課題】全身性硬化症、線維症（例えば、肺線維症）、軟骨無形成症、致死性骨異形成症（例えば、Ｉ型）、発育遅延及び黒色表皮腫を伴う重度の軟骨無形成症（ＳＡＤＤＡＮ）、ムエンケ症候群、又はがんの治療に使用するための化合物等の提供。【解決手段】以下の式の化合物、又はその薬学的に許容される塩が提供される。TIFF2024099714000541.tif4196（式中、Ａ：Ｒ１及びＲ１Ａ置換のピラゾール、トリアゾールなど。Ｘ１、Ｘ２：Ｎ、Ｃ。Ｘ３：Ｎ、ＣＨ。Ｘ４：Ｎ、ＣＲ９。Ｙ：ＮＨ、Ｏ、Ｓ、結合。Ｙ１：結合、ＣＨＲ７など。Ｙ２：結合、ＣＨＲ３など。Ｙ３:ＣＲ４Ｒ５、ＣＦ２。Ｙ４:ＣＲ３Ｒ４、ＣＦ２。Ｚ：結合、ＣＲ４Ｒ４Ａなど。Ｚ１：結合、ＣＨ２、ＣＨ２ＣＨ２。）【選択図】なし