SUBSTITUTED AMINOQUINOLONES AS DGK ALPHA INHIBITORS FOR IMMUNE ACTIVATION

To provide compounds useful for the treatment of diacylglycerol kinase α regulated disorders.SOLUTION: The present invention provides aminoquinolone compounds of general formula (I), methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical composi...

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Hauptverfasser:	CHRISTIAN LECHNER, DIRK KOSEMUND, DETLEF STOECKIGT, NICOLAS WERBECK, NGUYEN THI THANH UYEN, SIMON ANTHONY HERBERT, CHRISTINA KOBER, DENNIS KIRCHHOFF, KIRSTIN PETERSEN, MAREIKE GREES, NORBERT SCHMEES, ISABEL PATRIZIA KERSCHGENS, LARS WORTMANN, BENJAMIN BADER, RIENK OFFRINGA, ROBIN MICHAEL MEIER, ULF BOEMER
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide compounds useful for the treatment of diacylglycerol kinase α regulated disorders.SOLUTION: The present invention provides aminoquinolone compounds of general formula (I), methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds and the use of the compounds for preparing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase α regulated disorders, as a sole agent or in combination with other active ingredients.SELECTED DRAWING: None 【課題】ジアシルグリセロールキナーゼα制御障害の治療に有効な化合物を提供する。【解決手段】一般式（Ｉ）のアミノキノロン化合物、前記化合物の製造方法、前記化合物の製造に有用である中間体化合物、前記化合物を含む医薬組成物及び組み合わせ、及び疾患、特には単剤として又は他の有効成分との組み合わせでの、ジアシルグリセロールキナーゼα制御障害の治療及び／又は予防のための医薬組成物の製造のための前記化合物の使用を含む。TIFF2024099684000862.tif58153【選択図】なし