DESIGNED BACTERIAL COMPOSITIONS AND USES THEREOF

To provide bacterial compositions useful for treating and preventing complications and side effects associated with diseases or disorders, such as diseases or disorders associated with dysbiosis imbalance of the gastrointestinal tract.SOLUTION: Provided is a composition comprising a first purified bacterial population and a second purified bacterial population, which comprises one or more bacteria having a specific DNA sequence, the second purified bacterial population comprising one or more bacteria having one or more features selected from the group consisting of: (i) capable of engrafting when administered to a subject, (ii) capable of having anti-inflammatory activity, (iii) not capable of inducing pro-inflammatory activity, (iv) capable of producing a secondary bile acid, (v) capable of producing a tryptophan metabolite, (vi) capable of restoring epithelial integrity as determined by a primary epithelial cell monolayer barrier integrity assay, (vii) capable of being associated with remission of an inflammatory bowel disease, and (viii) capable of producing a short-chain fatty acid.SELECTED DRAWING: Figure 1 【課題】疾患または障害、例えば、胃腸管の腸内菌共生バランス失調と関連する疾患または障害と関連する合併症及び副作用を処置及び予防するために有用である細菌組成物を提供する。【解決手段】第１の精製細菌集団及び第２の精製細菌集団を含む組成物であって、特定のＤＮＡ配列を有する１種または複数の細菌を含み、かつ第２の精製細菌集団が、（ｉ）対象に投与された場合に生着し得る；（ｉｉ）抗炎症活性を有し得る、（ｉｉｉ）炎症誘発性活性を誘導し得ない、（ｉｖ）二次胆汁酸を産生し得る、（ｖ）トリプトファン代謝産物を産生し得る、（ｖｉ）一次上皮細胞単層関門完全性アッセイにより決定されるとおり、上皮完全性を回復させ得る、（ｖｉｉ）炎症性腸疾患の寛解と関連し得る、（ｖｉｉｉ）短鎖脂肪酸を産生し得る等の特徴からなる群から選択される１つまたは複数の特徴を有する１種または複数の細菌を含む、前記組成物である。【選択図】図１