NEUROFILAMENT PROTEIN FOR GUIDING THERAPEUTIC INTERVENTION IN AMYOTROPHIC LATERAL SCLEROSIS

To provide a neurofilament protein for guiding therapeutic intervention in amyotrophic lateral sclerosis.SOLUTION: In one aspect, the invention provides a method for alleviating a symptom in a patient with amyotrophic lateral sclerosis, the method comprising administering an efficacious therapeutic...

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Hauptverfasser:	STEVE SANG-WOO HAN, GIULIO SRUBEK-TOMASSY, TOBY ARLO FERGUSON, ALEXANDER REID VINCENT MCCAMPBELL, DANIELLE LEEZETTA GRAHAM
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide a neurofilament protein for guiding therapeutic intervention in amyotrophic lateral sclerosis.SOLUTION: In one aspect, the invention provides a method for alleviating a symptom in a patient with amyotrophic lateral sclerosis, the method comprising administering an efficacious therapeutic to the patient. When administered to the patient, the efficacious therapeutic results in a level of a neurofilament protein in a biological sample of the patient that is lower than a level of neurofilament protein in a patient with amyotrophic lateral sclerosis not dosed with the therapeutic. In some embodiments, the patient is currently being dosed with or has formerly been dosed with either a non-efficacious therapeutic or a therapeutic that is different than the efficacious therapeutic.SELECTED DRAWING: None 【課題】筋萎縮性側索硬化症における治療的介入を導くためのニューロフィラメントタンパク質の提供。【解決手段】一態様では、本発明は、筋萎縮性側索硬化症患者の症状を緩和するための方法を提供し、患者に有効な治療薬を投与することを含み、有効な治療薬は、患者に投与される時、治療薬を投与されていない筋萎縮性側索硬化症患者のニューロフィラメントタンパク質のレベルよりも低い、患者の生体試料中のニューロフィラメントタンパク質のレベルをもたらす。一部の実施形態では、患者は、有効でない治療薬または有効な治療薬とは異なる治療薬のいずれかを、現在投与されているか、または以前に投与されている。【選択図】なし