BONE METABOLISM IMPROVER

To provide a bone metabolism improver composed of a novel ingredient.SOLUTION: A feature of the present invention for solving the problem is as follows: 1) an osteoclast differentiation inhibitor containing at least one of ferulic acid, astaxanthin, α-lipoic acid, Coprinus comatus extract, Cistanche...

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Hauptverfasser: OGURA SHOJI, KAKIHARA YOSHITO, SHIMODA HIROSHI
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:To provide a bone metabolism improver composed of a novel ingredient.SOLUTION: A feature of the present invention for solving the problem is as follows: 1) an osteoclast differentiation inhibitor containing at least one of ferulic acid, astaxanthin, α-lipoic acid, Coprinus comatus extract, Cistanche plant extract, Subgen. Cerasus extract, γ-oryzanol, plant- and/or processed plant-derived polyamine composition, and Petasites extract as an active ingredient; 2) an osteoblast differentiation promotor containing at least one of α-lipoic acid, Cistanche plant extract, and ferulic acid as an active ingredient; 3) a promoter for expression of BSPII in an osteoblast precursor containing Cistanche plant extract as an active ingredient; 4) a promoter for expression of type 1 collagen in an osteoblast precursor containing Cistanche plant extract as an active ingredient; and 5) a bone metabolism improver containing at least one agent of 1) to 4) as an active ingredient.SELECTED DRAWING: None 【課題】 新規な成分の骨代謝改善剤を提供する。【解決手段】 上記課題を解決するための本発明の特徴は以下の通りである。1. フェルラ酸、アスタキサンチン、α-リポ酸、 ササクレヒトヨタケエキス、ハマウツボ科の植物エキス、桜エキス、 γ-オリザノール、植物及び/または植物加工物由来のポリアミン組成物、フキエキスのうちの少なくとも1種を有効成分とする破骨細胞の分化抑制剤。2.α-リポ酸、ハマウツボ科の植物エキス、フェルラ酸のうちの少なくとも1種を有効成分とする骨芽細胞の分化促進剤。3.ハマウツボ科の植物エキスを有効成分とする前駆骨芽細胞におけるBSPII発現促進剤。4.ハマウツボ科の植物エキスを有効成分とする前駆骨芽細胞における1型コラーゲン発現促進剤。5.上記1.~上記4.のうちの少なくとも1つの剤を有効成分とする骨代謝改善剤。【選択図】なし