BISOPROLOL-CONTAINING PATCH

BISOPROLOL-CONTAINING PATCH

To provide a patch that prevents bisoprolol analogs from increasing with time.SOLUTION: A patch includes an adhesive layer on a support. The adhesive layer includes bisoprolol or a pharmaceutically acceptable salt thereof, an adhesive base, L-cysteine, and a silicate compound. In the adhesive layer,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHINODA TOMOHIRO, TAKAMI ATSUO, TAMURA RYOMA
Format: Patent
Sprache:eng ; jpn
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:To provide a patch that prevents bisoprolol analogs from increasing with time.SOLUTION: A patch includes an adhesive layer on a support. The adhesive layer includes bisoprolol or a pharmaceutically acceptable salt thereof, an adhesive base, L-cysteine, and a silicate compound. In the adhesive layer, the value calculated by the formula: L-cysteine content (mass%)×silicate compound content (mass%)/bisoprolol content (mass%) is 0.016-0.5.SELECTED DRAWING: None 【課題】時間経過してもビソプロロールの類縁物質が増加し難い貼付剤を提供すること。【解決手段】支持体上に粘着剤層を備える貼付剤であって、上記粘着剤層が、ビソプロロール又はその薬学的に許容可能な塩と、粘着基剤と、Ｌ－システインと、ケイ酸化合物を含有し、上記粘着剤層において式：Ｌ－システインの含有量（質量％）×ケイ酸化合物の含有量（質量％）／ビソプロロールの含有量（質量％）で算出される値が０．０１６～０．５である、貼付剤。【選択図】なし