ANTI-FLT-1 ANTIBODIES FOR TREATING DUCHENNE MUSCULAR DYSTROPHY

To provide anti-FLT-1 antibodies in the treatment of Duchenne muscular dystrophy.SOLUTION: The present invention provides, among other things, anti-Flt-1 antibodies and methods for treating muscular dystrophy, in particular, Duchenne muscular dystrophy (DMD). In some embodiments, a method according...

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Bibliographische Detailangaben
Hauptverfasser:	HANS DE HAARD, SOFIE GABRIELS, DENNIS KEEFE, NATALIE DE JONGE
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide anti-FLT-1 antibodies in the treatment of Duchenne muscular dystrophy.SOLUTION: The present invention provides, among other things, anti-Flt-1 antibodies and methods for treating muscular dystrophy, in particular, Duchenne muscular dystrophy (DMD). In some embodiments, a method according to the present invention includes administering to an individual who is suffering from or susceptible to DMD an effective amount of an anti-Flt-1 antibody or antigen-binding protein thereof so as to reduce intensity, severity, or frequency of at least one symptom or feature of DMD, or to delay DMD onset.SELECTED DRAWING: None 【課題】デュシェンヌ型筋ジストロフィーの治療における抗ＦＬＴ－１抗体の提供。【解決手段】本発明はとりわけ、筋ジストロフィー、特にデュシェンヌ型筋ジストロフィー（ＤＭＤ）を治療するための抗Ｆｌｔ－１抗体及び方法を提供する。いくつかの実施形態において、本発明による方法は、ＤＭＤの少なくとも１つの症状または特徴が強度、重症度もしくは頻度において減少するように、またはその発症が遅延するように、ＤＭＤを患っているまたはそれを患いやすい個体に、抗Ｆｌｔ－１抗体またはその抗原結合タンパク質の治療に有効な量を投与することを含む。【選択図】なし