DEACETOXY CEPHALOSPORIN C-PRODUCING BACTERIAL STRAIN FOR 7-ADCA PRODUCTION WITH HIGH CONCENTRATION AND HIGH PURITY, AND PRODUCTION METHOD USING THE SAME

To develop a bacterial strain that can produce the target substance DAOC at high purity with productivity increased for deacetoxy cephalosporin C (DAOC) and decreased for byproducts.SOLUTION: Disclosed herein are a bacterial strain with excellent deacetoxy cephalosporin C (DAOC) productivity and a u...

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Hauptverfasser: PARK CHOL, KIM SEUNG KI, KANG MI SUK, LI HONG XIAN, JO TOICHI, CHOI YEON HEE, YUN YOUNG SUNG, JEONG DONG WON, LEE JI SU, LEE HYEON SEO, PIAO XUE MEI, KIM YU MI
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:To develop a bacterial strain that can produce the target substance DAOC at high purity with productivity increased for deacetoxy cephalosporin C (DAOC) and decreased for byproducts.SOLUTION: Disclosed herein are a bacterial strain with excellent deacetoxy cephalosporin C (DAOC) productivity and a use thereof. A mutant bacterial strain with improved DAOC productivity and a use thereof for producing 7-amino deacetoxy cephalosporanic acid (7-ADCA) are provided.SELECTED DRAWING: Figure 4 【課題】デアセトキシセファロスポリンC(Deacetoxy cephalosporin C;DAOC)生産性を高め、副産物の生産性を低めることで、目的物質であるDAOCの純度が高い生産菌株の開発。【解決手段】デアセトキシセファロスポリンC(Deacetoxy cephalosporin C;DAOC)生産能に優れた菌株およびその用途に関するものであって、改善されたDAOC生産能を有する変異菌株およびその7-ADCA(7-Amino deacetoxy cephalosporanic acid)の製造のための用途が提供される。【選択図】図4