SYSTEM AND METHOD FOR DELIVERING DRUG COMPRISING POLYSIALIC ACID AND/OR OTHER POLYMERS

To provide particles that can access the interior of cells and procure the intracellular release of drugs.SOLUTION: There is provided a composition comprising a plurality of nanoentities comprising an inner portion surrounded with an outer shell, in which the outer shell includes a polymer and a tar...

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Bibliographische Detailangaben
Hauptverfasser: CARMEN MARIA TEIJEIRO VALINO, DESIREE TEIJEIRO OSORIO, MARIA JOSE ALONSO FERNANDEZ, ANA CADETE PIRES
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:To provide particles that can access the interior of cells and procure the intracellular release of drugs.SOLUTION: There is provided a composition comprising a plurality of nanoentities comprising an inner portion surrounded with an outer shell, in which the outer shell includes a polymer and a targeting moiety and the inner portion includes at least one hydrophobic compound, the polymer being selected from the group consisting of polysialic acid and/or pegylated-polysialic acid, hyaluronic acid and/or pegylated-hyaluronic acid, polyglutamic acid and/or pegylated-polyglutamic acid, poly(aspartic acid) and/or pegylated-poly(aspartic acid), polylactic acid and/or pegylated polylactic acid, and mixtures thereof; and the hydrophobic compound being selected from the group consisting of oil, fatty acids, alkanes, cycloalkanes, bile salts, terpenoids, terpenes, fat-soluble vitamins, and surfactants.SELECTED DRAWING: None 【課題】細胞内部にアクセスし、薬物の細胞内での放出をもたらすことができる粒子を提供する。【解決手段】外殻に取り囲まれた内側部分を含み、外殻がポリマーと標的化部分とを含み、内側部分が少なくとも1つの疎水性化合物を含む、複数のナノカプセルを含んだ組成物であって、ポリマーは、、ポリシアル酸および/またはペグ化-ポリシアル酸、ヒアルロン酸および/またはペグ化-ヒアルロン酸、ポリグルタミン酸および/またはペグ化-ポリグルタミン酸、ポリ(アスパラギン酸)および/またはペグ化-ポリ(アスパラギン酸)、ポリ乳酸および/またはペグ化ポリ乳酸、ならびにそれらの混合物から成る群から選択される、疎水性化合物は、油、脂肪酸、アルカン、シクロアルカン、胆汁酸塩、テルペノイド、テルペン、脂溶性ビタミン、および界面活性剤から成る群から選択される組成物とする。【選択図】なし