METHOD FOR ASSISTING DETECTION OF HEPATOMA

To provide a method for assisting detection of hepatoma with which hepatoma can be detected with higher sensitivity than a known method.SOLUTION: A method for assisting detection of hepatoma includes measuring full-length glypican-3 in a blood specimen separated from a living body, and measuring gly...

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Bibliographische Detailangaben
Hauptverfasser:	NISHII TOMONORI, YAGI SHINTARO, AOYANAGI KATSUMI, NOJIMA HISASHI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Beschreibung
Zusammenfassung:	To provide a method for assisting detection of hepatoma with which hepatoma can be detected with higher sensitivity than a known method.SOLUTION: A method for assisting detection of hepatoma includes measuring full-length glypican-3 in a blood specimen separated from a living body, and measuring glypican-3 having an N-terminus sub-unit. The method includes taking the ratio of a measured value of the full-length glypican-3 to a measured value of the glypican-3 having an N-terminus sub-unit (measured value of full-length glypican-3/measured value of glypican-3 having N-terminus sub-unit), and the ratio higher than that of an able-bodied person indicates the possibility that the living body has hepatoma.SELECTED DRAWING: Figure 1 【課題】公知の方法よりも高感度に肝細胞がんを検出することが可能な、肝細胞がんの検出を補助する方法を提供すること。【解決手段】肝細胞がんの検出を補助する方法は、生体から分離された血液検体中の全長グリピカン－３を測定することと、Ｎ末端側サブユニットを有するグリピカン－３を測定することとを含む。全長グリピカン－３の測定値とＮ末端側サブユニットを有するグリピカン－３の測定値との比（全長グリピカン－３の測定値／Ｎ末端側サブユニットを有するグリピカン－３の測定値）が、健常者よりも高いことが、生体が肝細胞がんに罹患している可能性が高いことを示す。【選択図】図１