CRISPR/CAS-RELATED METHODS AND COMPOSITIONS FOR TREATING HERPES SIMPLEX VIRUS

To provide compositions and methods for the treatment, prevention and/or reduction of HSV-1 and HSV-2 infections.SOLUTION: A genome editing system comprises: a gRNA molecule comprising a targeting domain that is complementary with a target sequence of a Herpes simplex virus (HSV) viral gene selected...

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Hauptverfasser:	PENROSE ODONNELL, DAVID A BUMCROT, ARI E FREIDLAND
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide compositions and methods for the treatment, prevention and/or reduction of HSV-1 and HSV-2 infections.SOLUTION: A genome editing system comprises: a gRNA molecule comprising a targeting domain that is complementary with a target sequence of a Herpes simplex virus (HSV) viral gene selected from the group consisting of a RS1 gene, a RL2 gene, and a LAT gene; and a Cas9 molecule.SELECTED DRAWING: Figure 1A 【課題】ＨＳＶ－１及びＨＳＶ－２感染症を治療、予防、及び／又は低減する組成物、及び方法を提供する。【解決手段】ＲＳ１遺伝子、ＲＬ２遺伝子、及びＬＡＴ遺伝子からなる群から選択される単純ヘルペスウイルス（ＨＳＶ）ウイルス遺伝子の標的配列と相補的な標的指向性ドメインを含むｇＲＮＡ分子、及びＣａｓ９分子を含むゲノム編集系を提供する。【選択図】図１Ａ