3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONE AS MEK INHIBITOR

To provide a pharmaceutical composition, effective for treating tumors mediated by MEK, including therapies that can target tumors in the CNS by penetrating the blood-brain barrier (BBB) and/or blood-CSF barrier (BCSFB).SOLUTION: The present invention provides a compound of formula (I) or a pharmace...

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Bibliographische Detailangaben
Hauptverfasser:	WESLEY DAVID CLARK, JAMES FRANCIS BLAKE, JENNIFER LYNN FULTON, DAVID AUSTIN MORENO, SIDNIE TAYLER BLANCHET, JOSHUA RYAN DAHLKE, ALLEN SHELLEY, REN LI, ALEX ANDREW KELLUM, PATRICK MICHAEL DOERNER BARBOUR, MARK LAURENCE BOYS, ELLEN MARGARET KNAPP, FAITH ELIZABETH WITKOS, JACOB MATTHEW O'LEARY, CONOR JAMES KAUDORI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide a pharmaceutical composition, effective for treating tumors mediated by MEK, including therapies that can target tumors in the CNS by penetrating the blood-brain barrier (BBB) and/or blood-CSF barrier (BCSFB).SOLUTION: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising such a compound and salt. The present invention further provides a solid form of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.SELECTED DRAWING: None 【課題】血液脳関門（ＢＢＢ）および／または血液ＣＳＦ関門（ＢＣＳＦＢ）に浸透し、ＣＮＳにおける腫瘍を標的にすることができる治療を含む、ＭＥＫによって媒介される腫瘍の治療に有用な医薬組成物を提供する。【解決手段】式（Ｉ）の化合物または薬学的に許容できるその塩、そのような化合物および塩を含む医薬組成物を提供する。さらに、８－（（２－フルオロ－４－（メチルチオ）フェニル）アミノ）－２－（２－ヒドロキシエトキシ）－７－メチル－３，４－ジヒドロ－２，７－ナフチリジン－１，６（２Ｈ，７Ｈ）－ジオンの固体形態を提供する。TIFF2024047569000139.tif5154【選択図】なし