METHODS AND ASSAYS FOR MODULATING GENE TRANSCRIPTION BY MODULATING CONDENSATES

To provide methods and assays for modulating gene transcription by modulating condensates.SOLUTION: A method of modulating transcription of one or more genes comprises modulating formation, composition, maintenance, dissolution, activity and/or regulation of a condensate associated with the one or m...

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Hauptverfasser:	ISAAC KLEIN, OZGUR OKSUZ, RICHARD A YOUNG, ALICIA V ZAMUDIO, CHARLES H LI, LENA K AFEYAN, ABRAHAM S WEINTRAUB, JURIAN SCHUIJERS, ALESSANDRA DALL'AGNESE, BRIAN J ABRAHAM, NANCY M HANNETT, JOHN C MANTEIGA, BENJAMIN R SABARI, DANIEL S DAY, YANG E GUO, PHILLIP A SHARP, ARUP K CHAKRABORTY, ELIOT COFFEY, ANN BOIJA, LEE TONG IHN, JONATHAN E HENNINGER, KRISHNA SHRINIVAS
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide methods and assays for modulating gene transcription by modulating condensates.SOLUTION: A method of modulating transcription of one or more genes comprises modulating formation, composition, maintenance, dissolution, activity and/or regulation of a condensate associated with the one or more genes, where the condensate is a transcriptional condensate, a heterochromatin condensate, or a condensate physically associated with an mRNA initiation or elongation complex.SELECTED DRAWING: None 【課題】凝縮体を調節することによって遺伝子の転写を調節するための方法及びアッセイを提供すること。【解決手段】１つ以上の遺伝子の転写を調節する方法であって、前記方法が、前記１つ以上の遺伝子と結び付く凝縮体の形成、組成、維持、崩壊、活性、及び／または制御を調節することを含み、前記凝縮体が、転写凝縮体、ヘテロクロマチン凝縮体、またはｍＲＮＡ開始複合体もしくはｍＲＮＡ伸長複合体と物理的に結び付く凝縮体である、前記方法。【選択図】なし