ANTI-CUB DOMAIN-CONTAINING PROTEIN 1 (CDCP1) ANTIBODIES, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE THEREOF

To provide anti-CDCP1 antibodies and ADCs that can be used for therapeutic purposes in treatment of cancer.SOLUTION: In certain aspects, the present invention provides anti-CDCP1 antibodies and antibody drug conjugates (ADCs). In certain embodiments of the invention, the antibodies, or antigen bindi...

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Bibliographische Detailangaben
Hauptverfasser:	SCOTT MICHAEL LONNING, GU TINGLEI, KLARISA RIKOVA, ALEKSANDR TKACHEV, NELS ERIC PEDERSON, REN HONG
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide anti-CDCP1 antibodies and ADCs that can be used for therapeutic purposes in treatment of cancer.SOLUTION: In certain aspects, the present invention provides anti-CDCP1 antibodies and antibody drug conjugates (ADCs). In certain embodiments of the invention, the antibodies, or antigen binding portions thereof, bind to CDCP1 (e.g., the amino acid sequence provided in GenBank Accession No. NP_073753.3 and/or the amino acid sequence provided in NP_835488.1, the entire contexts of each of which are incorporated herein by reference), or the extracellular domain of CDCP1.SELECTED DRAWING: Figure 1 【課題】がんの処置において治療目的に使用することができる抗ＣＤＣＰ１抗体およびＡＤＣを提供する。【解決手段】ある特定の態様では、本発明は、抗ＣＤＣＰ１抗体および抗体薬物コンジュゲート（ＡＤＣ）を提供する。本発明のある特定の実施形態では、抗体またはその抗原結合性部分は、ＣＤＣＰ１（例えば、ＧｅｎＢａｎｋ受託番号ＮＰ＿０７３７５３．３に提供されているアミノ酸配列および／またはＮＰ＿８３５４８８．１に提供されているアミノ酸配列。これらの各々の全内容は、参照により本明細書に組み込まれる）またはＣＤＣＰ１の細胞外ドメインに結合する。【選択図】図１