NUCLEIC-ACID-CONTAINING LIPID NANOPARTICLES

To provide a nucleic acid-containing lipid nanoparticle that is useful as a medicament and is more stable than conventional particles.SOLUTION: The present invention provides a nucleic acid-containing lipid nanoparticle comprising an analog of a fatty acid ester of glycerol, and a nucleic acid, wher...

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Bibliographische Detailangaben
Hauptverfasser:	HATANAKA KENTARO, HOSOE SHINTARO, MAEMOTO MICHIHIRO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide a nucleic acid-containing lipid nanoparticle that is useful as a medicament and is more stable than conventional particles.SOLUTION: The present invention provides a nucleic acid-containing lipid nanoparticle comprising an analog of a fatty acid ester of glycerol, and a nucleic acid, wherein the analog is not hydrolyzable by a lipase.SELECTED DRAWING: None 【課題】医薬として有用で、従来の粒子に比して安定な核酸含有脂質ナノ粒子を提供する。【解決手段】リパーゼによって加水分解されない、グリセロールの脂肪酸エステル類縁体、および核酸を含む、核酸含有脂質ナノ粒子を提供する。【選択図】なし