AGENT FOR INDUCTION OF APOPTOSIS IN UNDIFFERENTIATED STEM CELL, AND METHOD FOR PURIFICATION OF DIFFERENTIATED CELL

To provide methods for the induction of apoptosis in undifferentiated stem cells, using less quantities of material, applicable even to cells in a spheroidal shape, and agents therefor.SOLUTION: The present invention provides an agent for the induction of apoptosis in pluripotent stem cells or cells...

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Hauptverfasser:	KANAAMI SAYAKA, FUKUDA KEIICHI, TOYAMA SHUGO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide methods for the induction of apoptosis in undifferentiated stem cells, using less quantities of material, applicable even to cells in a spheroidal shape, and agents therefor.SOLUTION: The present invention provides an agent for the induction of apoptosis in pluripotent stem cells or cells with differentiation potential induced from the pluripotent stem cells, comprising as an active ingredient at least one compound selected from the group consisting of TVB-3166 or analogs thereof, TVB-3664 or analogs thereof, TVB-2640 or analogs thereof, FAS-IN-1 tosylate or analogs thereof, and FT113 or analogs thereof.SELECTED DRAWING: None 【課題】より少ない量で、また細胞がスフェロイド状でも未分化幹細胞の細胞死誘導を行える方法、その為の薬剤を提供することを目的とする。【解決手段】ＴＶＢ－３１６６又はその類縁体、ＴＶＢ－３６６４又はその類縁体、ＴＶＢ－２６４０又はその類縁体、ＦＡＳ－ＩＮ－１ｔｏｓｙｌａｔｅ又はその類縁体、及びＦＴ１１３又はその類縁体からなる群より選択される少なくとも1種の化合物を有効成分として含有する、多能性幹細胞又は前記多能性幹細胞から誘導された分化多能性を有する細胞の細胞死誘導剤、等。【選択図】なし