IMMUNOMODULATORY SMALL HAIRPIN RNA MOLECULES

To provide specific and potent RNA species which can modulate RIG-I mediated immune response.SOLUTION: The present invention generally relates to specific immune-modulatory RNA species that have a small hairpin structure (shRNA), and that can bind to retinoic acid inducible gene I receptor (RIG-I)....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LUO DAHAI, KATJA FINK, YONG HUI YEE, VICTOR CHIN-YONG HO
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To provide specific and potent RNA species which can modulate RIG-I mediated immune response.SOLUTION: The present invention generally relates to specific immune-modulatory RNA species that have a small hairpin structure (shRNA), and that can bind to retinoic acid inducible gene I receptor (RIG-I). In particular, the RNA species comprise a nucleotide insertion to create a kink in the stem region. Also encompassed are compositions comprising such shRNA, for use as antiviral or anticancer medication, or as adjuvants in vaccine.SELECTED DRAWING: Figure 1A 【課題】ＲＩＧ－Ｉ媒介性免疫応答を調節することができる特異的で強力なＲＮＡ種を提供する。【解決手段】本発明は、概して、低分子ヘアピン構造（ｓｈＲＮＡ）を有し、レチノイン酸誘導性遺伝子Ｉ受容体（ＲＩＧ－Ｉ）に結合することができる特異的な免疫調節性ＲＮＡ種を開示する。特に、前記ＲＮＡ種は、ステム領域にキンクを創出するためのヌクレオチド挿入を含む。また、抗ウイルス薬剤もしくは抗がん薬剤としてまたはワクチン中のアジュバントとして使用するための、そのようなｓｈＲＮＡを含む組成物が包含される。【選択図】図１Ａ