ANTI-ANGIOPOIETIN-2 ANTIBODIES AND USES THEREOF

To provide antibodies or antigen-binding fragments thereof that specifically bind to human angiopoietin 2 and induce Tie2 activation.SOLUTION: Provided are an anti-Ang2 antibody having a particular sequence having a dual function of activating the Tie2 receptor together with neutralizing Ang2, the a...

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Hauptverfasser:	KIM JAERYUNG, SEO SU JIN, OH WANGYUHL, PARK JANG RYUL, BAE JEOMIL, KOH GOU YOUNG, PARK JIN-SUNG, KIM PILHAN, KIM MI JEONG
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide antibodies or antigen-binding fragments thereof that specifically bind to human angiopoietin 2 and induce Tie2 activation.SOLUTION: Provided are an anti-Ang2 antibody having a particular sequence having a dual function of activating the Tie2 receptor together with neutralizing Ang2, the antibody showing the property of normalizing abnormal and pathological blood vessels, and thus exhibiting therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels; an angiogenesis inhibitor; as well as a composition for prevention and treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient; and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.SELECTED DRAWING: None 【課題】ヒトアンジオポエチン２に特異的に結合しＴｉｅ２活性化を誘導する、抗体またはその抗原結合フラグメントを提供する。【解決手段】Ａｎｇ２を中和すると共にＴｉｅ２受容体を活性化するという、二重の機能を有する特定の配列を有する抗Ａｎｇ２抗体であって、異常な、および病的な血管を正常化する作用を示し、したがって異常な血管が関与するさまざまな疾患または障害に対する処置効果を示す抗体。血管新生抑制剤、ならびに異常なＡｎｇ２発現およびＴｉｅ２調節異常に関連する疾患を予防および治療するための、抗体を活性成分として含む組成物、およびＡｎｇ２抑制およびＴｉｅ２活性化に関連する疾患診断用の、抗体を含む組成物を提供する。【選択図】なし