ANTI-TISSUE FACTOR ANTIBODIES, ANTIBODY-DRUG CONJUGATES, AND RELATED METHODS

To provide antibodies that specifically bind to human tissue factor (TF), to provide anti-TF antibody-drug conjugates (ADCs), and to provide compositions comprising the antibody or ADC.SOLUTION: Provided is an isolated human antibody which binds to the extracellular domain of human Tissue Factor (TF...

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Bibliographische Detailangaben
Hauptverfasser:	ALLEN G CAI, THI-SAU MIGONE, JAN-WILLEM THEUNISSEN, ANDREW D AVERY II, ANTHONY BYRON COOPER
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide antibodies that specifically bind to human tissue factor (TF), to provide anti-TF antibody-drug conjugates (ADCs), and to provide compositions comprising the antibody or ADC.SOLUTION: Provided is an isolated human antibody which binds to the extracellular domain of human Tissue Factor (TF), the isolated human antibody binding human TF at a human TF binding site that is distinct from a human TF binding site bound by human FVIIa.SELECTED DRAWING: None 【課題】ヒト組織因子（ＴＦ）に特異的に結合する抗体、抗ＴＦ抗体薬物コンジュゲート（ＡＤＣ）、及び該抗体またはＡＤＣを含む組成物を提供する。【解決手段】ヒト組織因子（ＴＦ）の細胞外ドメインに結合する単離されたヒト抗体であって、ヒトＦＶＩＩａが結合するヒトＴＦ結合部位とは別個のヒトＴＦ結合部位でヒトＴＦに結合する、前記単離されたヒト抗体が提供される。【選択図】なし