CELL MEMBRANE-PERMEABLE MOLECULE AND USE THEREOF

To provide: a cell membrane-permeable molecule that has a function of incorporating active ingredients into cells while having low toxicity to living organisms; a peptide complex containing the cell membrane permeable molecule and a production method thereof; a peptide library containing the peptide...

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Bibliographische Detailangaben
Hauptverfasser:	SHIKAKURA TOSHIHIRO, KOMIYA CHIAKI, FUJII TOSHIHIDE, KITANO MITSUAKI, HIRAYAMA YUSUKE, IGUCHI KEITA
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY COMBINATORIAL CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	To provide: a cell membrane-permeable molecule that has a function of incorporating active ingredients into cells while having low toxicity to living organisms; a peptide complex containing the cell membrane permeable molecule and a production method thereof; a peptide library containing the peptide complex; and a screening method for a functional peptide using the peptide library.SOLUTION: A cell membrane-permeable molecule has a structure represented by the specified general formula (I), and is in the form of a salt with an acid having a pKa value lower than 4.7.SELECTED DRAWING: None 【課題】有効成分を細胞内に取り込む機能を有しつつ、生体に対する毒性が低い細胞膜透過性分子、前記細胞膜透過性分子を含むペプチド複合体及びその製造方法、前記ペプチド複合体を含むペプチドライブラリ、及び前記ペプチドライブラリを用いた機能性ペプチドのスクリーニング方法を提供する。【解決手段】下記一般式（Ｉ）で表される構造を有し、ｐＫａの値が４．７未満の酸との塩であることを特徴とする細胞膜透過性分子である。【選択図】なし