CANCER STEM CELL SPECIFIC MOLECULE

To provide pharmaceutical compositions that can be used as anticancer agents, drug tolerant anti-cancer therapeutics, cancer recurrence inhibitors, cancer metastasis inhibitors, or postoperative adjuvant therapeutic agents which contain as an active ingredient a cell surface molecule that is specifi...

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Bibliographische Detailangaben
Hauptverfasser:	WATANABE TAKESHI, KATO ATSUHIKO, MATSUBARA KYOICHI, YAMAZAKI TATSUMI, SUZUKI MASAMI, OKABE TAKAFUMI, KOBAYASHI CHIKAHIRO, NATORI OSAMU
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide pharmaceutical compositions that can be used as anticancer agents, drug tolerant anti-cancer therapeutics, cancer recurrence inhibitors, cancer metastasis inhibitors, or postoperative adjuvant therapeutic agents which contain as an active ingredient a cell surface molecule that is specific to a Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) positive cancer stem cell with high proliferation potency and to a Lgr5 negative cancer stem cell with low proliferation potency, or an antibody to cell surface molecules thereof.SOLUTION: The present invention provides a pharmaceutical composition containing at least one antibody binding to a particular sequence of Lgr5.SELECTED DRAWING: None 【課題】増殖能の高いロイシン-リッチ-リピート含有Gタンパク質共役受容体5（Lgr5）陽性癌幹細胞と増殖能の低いLgr5陰性癌幹細胞に特異的な細胞表面分子、またこれらの細胞表面分子に対する抗体を有効成分として含有する抗癌剤、薬剤抵抗性癌治療剤、癌再発抑制剤、癌転移抑制剤または術後アジュバント療法剤として使用できる医薬組成物の提供。【解決手段】Ｌｇｒ５の特定の配列に結合する少なくとも一つの抗体を含有する医薬組成物。【選択図】なし