EXPRESSION OF PNEUMOCOCCAL SURFACE PROTEIN A (PspA)

To provide an expression construct capable of stably and constitutively or inducibly expressing a high level of truncated pneumococcal surface protein A1 (PspA1) in bacteria.SOLUTION: The present invention provides an expression construct allowing high-level expression of truncated pneumococcal surf...

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Bibliographische Detailangaben
Hauptverfasser: NARENDER DEV MANTENA, RAJAN SRIRAMAN, RAMESH VENKAT MATUR, SWETHA KAMIREDDY, MAHIMA DATLA
Format: Patent
Sprache:eng ; jpn
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Zusammenfassung:To provide an expression construct capable of stably and constitutively or inducibly expressing a high level of truncated pneumococcal surface protein A1 (PspA1) in bacteria.SOLUTION: The present invention provides an expression construct allowing high-level expression of truncated pneumococcal surface protein A1 (PspA1), as set forth in specific sequences. The present invention provides an expression construct comprising a gene, which encodes truncated PspA1, as set forth in second specific sequences.SELECTED DRAWING: None 【課題】細菌において高レベルの切断型肺炎球菌表面タンパク質A1(PspA1)を安定的かつ構成的または誘導的に発現させることを可能にする発現構築物を提供する。【解決手段】本発明は、特定の配列に示される切断型肺炎球菌表面タンパク質A1(PspA1)の高レベル発現を可能にする発現構築物を提供する。本発明は、第2の特定の配列に示される切断型PspA1をコードする遺伝子を含む発現構築物を提供する。【選択図】なし