PHARMACEUTICAL FORMULATIONS FOR TREATING ENDOMETRIOSIS, UTERINE FIBROIDS, POLYCYSTIC OVARY SYNDROME OR ADENOMYOSIS

To provide orally bioavailable pharmaceutical compositions comprising a non-peptide GnRH antagonist.SOLUTION: A pharmaceutical composition comprises: 4-((R)-2-[5-(2-fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethylamino)-b...

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Hauptverfasser:	GREGORY A MCCLELLAND, AHMED M SOLIMAN, GEOFF ZHANG, OSCAR ANTUNEZ FLORES, PAUL M PELOSO, WING-KEUNG JUKI NG, JAMES W THOMAS, KEVIN C SPENCE, KEITH GORDON, JANINE D NORTH, JU TZUCHI R, JANE CASTELLI-HALEY, ANNA V STEPANENKO, DAVID METZGER, MICHAEL C SNABES, KRISTOF CHWALISZ, CHAROLOTTE D OWENS, RITA JAIN, LI YANXIA, SHAO XI, JAYANTHY JAYANTH, HANNAH PALAC
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide orally bioavailable pharmaceutical compositions comprising a non-peptide GnRH antagonist.SOLUTION: A pharmaceutical composition comprises: 4-((R)-2-[5-(2-fluoro-3-methoxy-phenyl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethylamino)-butyric acid or a pharmaceutically acceptable salt thereof; and an anti-gelling agent.SELECTED DRAWING: Figure 1 【課題】非ペプチドＧｎＲＨアンタゴニストを含む経口により生体利用可能な医薬組成物を提供すること。【解決手段】４－（（Ｒ）－２－［５－（２－フルオロ－３－メトキシ－フェニル）－３－（２－フルオロ－６－トリフルオロメチル－ベンジル）－４－メチル－２，６－ジオキソ－３，６－ジヒドロ－２Ｈ－ピリミジン－１－イル］－１－フェニル－エチルアミノ）－酪酸又は薬学的に許容されるその塩、及び抗ゲル化剤を含む医薬組成物を提供する。【選択図】図１