ANTIBODY LIBRARIES WITH MAXIMIZED DEVELOPABILITY CHARACTERISTICS

To provide antibody libraries with maximized developability characteristics.SOLUTION: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring hum...

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Bibliographische Detailangaben
Hauptverfasser:	ANDRE TEIXEIRA, ANDREW RAYMON MORTON BRADBURY, MICHAEL FRANK ERASMUS
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide antibody libraries with maximized developability characteristics.SOLUTION: Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.SELECTED DRAWING: Figure 1 【課題】抗体の開発可能性が最大化された抗体ライブラリーを提供すること。【解決手段】天然に存在するヒト抗体にみられる相補性決定領域（ＣＤＲ）を含む、複数の重鎖可変ドメイン及び／または複数の軽鎖可変ドメインを含む抗体ライブラリー、ならびにそのような抗体ライブラリーを作製する方法。抗体ライブラリーは、メンバーの１つ以上の特徴に影響を与える１つ以上のライアビリティを含むそのようなメンバーを含まない。さらに、抗体ライブラリーは、同じ天然に存在するヒト抗体にはみられない重鎖及び／または軽鎖ＣＤＲを有するメンバーを含む。【選択図】図１