1,4-DIAZOCANE COMPOUND OR SALT THEREOF

1,4-DIAZOCANE COMPOUND OR SALT THEREOF

To provide a novel method for producing an isoquinoline-6-sulfonamide derivative useful as a medicinal drug, and an intermediate which is used in the method.SOLUTION: A method for producing an isoquinoline-6-sulfonamide derivative of formula (11) or a salt thereof is provided, the method comprising...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: WASHIMI KENGO, MASUBUCHI KAZUNAO, KOIDE TOMOYUKI, TAKASHIMA YUJI, KIMATA OSAMU
Format: Patent
Sprache:eng ; jpn
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:To provide a novel method for producing an isoquinoline-6-sulfonamide derivative useful as a medicinal drug, and an intermediate which is used in the method.SOLUTION: A method for producing an isoquinoline-6-sulfonamide derivative of formula (11) or a salt thereof is provided, the method comprising reacting a 1,4-diazocane compound or a salt thereof with a quinoline-6-sulfonyl halide of formula (9) or a salt thereof, and then performing the elimination reaction of an amino protecting group.SELECTED DRAWING: None 【課題】医薬として有用なイソキノリン－６－スルホンアミド誘導体の新規製造法及びそれに用いる中間体の提供。【解決手段】１，４－ジアゾカン化合物又はその塩に、式（９）で表されるキノリン－６－スルホニルハライド又はその塩を反応させ、次いでアミノ保護基の脱離反応を行うことを特徴とする、式（１１）で表されるイソキノリン－６－スルホンアミド誘導体又はその塩の製造法。TIFF2023145577000035.tif17170TIFF2023145577000036.tif26170【選択図】なし