NOVEL THIOPHOSPHORAMIDITES

To provide oligonucleotides with improved physiochemical and pharmacological properties, including improved potency.SOLUTION: The present invention relates to a compound of formula (II) or (IIb). The compound of formula (II) can be used in the manufacture of oligonucleotides.SELECTED DRAWING: None 【...

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Bibliographische Detailangaben
Hauptverfasser:	KONRAD BLEICHER, HENRIK FRYDENLUND HANSEN, TROELS KOCH, WU YONG, MARTINA BRIGITTE DUSCHMALE, JOERG DUSCHMALE, ADRIAN SCHAEUBLIN, SHU XI, LI MEILING
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide oligonucleotides with improved physiochemical and pharmacological properties, including improved potency.SOLUTION: The present invention relates to a compound of formula (II) or (IIb). The compound of formula (II) can be used in the manufacture of oligonucleotides.SELECTED DRAWING: None 【課題】改良された効力を含む、改良された生理化学的特性および薬理学的特性を有するオリゴヌクレオチドを提供する。【解決手段】式(II)または(IIb)の化合物を提供する。式(II)の化合物をオリゴヌクレオチドの製造において使用することができる。TIFF2023139252000123.tif40153【選択図】なし