METHOD FOR PRODUCING AMINO ACID

METHOD FOR PRODUCING AMINO ACID

To provide a novel method for efficiently producing amino acids such as glycine using a microbe (enzyme) from a nitrile compound.SOLUTION: A method for producing glycine includes a step for having a nitrilase act on an aqueous solution including a nitrile compound under alkali conditions with a pH o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YAMAZAKI HIROSHI, KONISHI NORIKAZU, SUEOKA KENJI, KAJITANI HIDENOBU, KOSHIBA KEITA, SUGAI YUKI, TSUNEGA SEIJI, AKIYAMA TAKAMICHI
Format: Patent
Sprache:eng ; jpn
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:To provide a novel method for efficiently producing amino acids such as glycine using a microbe (enzyme) from a nitrile compound.SOLUTION: A method for producing glycine includes a step for having a nitrilase act on an aqueous solution including a nitrile compound under alkali conditions with a pH of 10.5 or higher. The method can use a nitrilase having a specific amino acid sequence, or an amino acid sequence being at least 80% identical to the amino acid sequence and encoding a protein having nitrilase activity.SELECTED DRAWING: None 【課題】ニトリル化合物から微生物（酵素）を用いてグリシンなどのアミノ酸を効率的に製造するための新規な方法を提供すること。【解決手段】ｐＨ１０．５以上のアルカリ条件下で、ニトリル化合物を含む水溶液にニトリラーゼを作用させる工程を含む、グリシンの製造方法。前記方法には、特定のアミノ酸配列を有するニトリラーゼ、または、前記アミノ酸配列と８０％以上の同一性を有し、ニトリラーゼ活性を有するタンパク質をコードするアミノ酸配列を使用することができる。【選択図】なし