ANTIBODIES SPECIFIC TO CD47 AND PD-L1

To provide antibodies that bind specifically to CD47 and PD-L1, a nucleic acid that codes for the antibody or an antigen-binding fragment thereof, an expression vector, a method of producing the antibody, and the use of the antibodies and compositions in cancer treatment.SOLUTION: The present invent...

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Hauptverfasser:	VALERIJ VLADIMIROVICH SOLOVEV, DMITRY VALENTINOVICH MOROZOV, ANDREI BORISOVICH ULITIN, KIRILL VLADIMIROVICH SOLOVYEV, TIMOFEJ ALEKSANDROVICH NEMANKIN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide antibodies that bind specifically to CD47 and PD-L1, a nucleic acid that codes for the antibody or an antigen-binding fragment thereof, an expression vector, a method of producing the antibody, and the use of the antibodies and compositions in cancer treatment.SOLUTION: The present invention provides a monoclonal antibody, which specifically binds to CD47 and PD-L1, comprising one binding site to CD47, and at least one binding site to PD-L1.SELECTED DRAWING: None 【課題】ＣＤ４７およびＰＤ－Ｌ１に特異的に結合する抗体、前記抗体またはその抗原結合断片をコードする核酸、発現ベクター、該抗体を得るための方法、ならびに癌療法における前記抗体および組成物の使用を提供する。【解決手段】ＣＤ４７およびＰＤ－Ｌ１に特異的に結合するモノクローナル抗体であって、ＣＤ４７に対する１つの結合部位、およびＰＤ－Ｌ１に対する少なくとも１つの結合部位を含む抗体を提供する。【選択図】なし