AGING BIOMARKER AND METHOD FOR DETECTING AGING STATE

To provide construction of a technique that can evaluate an aging state or onset or progress or the like of a specific disease objectively and with good repeatability, which is particularly an aging biomarker being an indicator of an aging state, and a method for detecting an aging state.SOLUTION: A...

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Hauptverfasser:	HASHIDA NORIYASU, ASAO KAZUNOBU, NAKAMURA SHOTA, MOTOOKA DAISUKE, NISHIDA KOJI, IIDA TETSUYA, ANDO MANABU
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	To provide construction of a technique that can evaluate an aging state or onset or progress or the like of a specific disease objectively and with good repeatability, which is particularly an aging biomarker being an indicator of an aging state, and a method for detecting an aging state.SOLUTION: An aging biomarker for detecting an aging state includes a bacterial species that belongs to one or more types of family selected from Corynebacteriaceae and Propionibacteriales in a superficial tissue of an eye, and a method for detecting an aging state includes a process of detecting a superficial tissue sample of an eye collected from a subject which is evaluated to be in an aging state when an abundance amount or an abundance ratio of Corynebacteriaceae bacterium exceeds an abundance amount or an abundance ratio of Propionibacteriales bacterium in a microbial flora included in the superficial tissue sample of an eye collected from the subject.SELECTED DRAWING: Figure 11 【課題】客観的かつ再現性良く老化状態や特定の疾患の発症や進行等を評価できる技術の構築、特には、老化状態の指標となる老化バイオマーカー及び老化状態の検出方法の提供を課題とする。【解決手段】老化状態を検出するための老化バイオマーカーであって、眼表面組織におけるCorynebacteriaceae科、及び、Propionibacteriales科から選択される１種以上の科に属する細菌種を含む老化バイオマーカー、及び、被験者から採取した眼表面組織検体に含まれる微生物叢において、Corynebacteriaceae科細菌の存在量又は存在割合がPropionibacteriales科細菌の存在量又は存在割合を上回ると、老化状態にあると評価される被験者から採取した眼表面組織検体を検出する工程を含む、老化状態の検出方法。【選択図】図１１