GPRC5D CHIMERIC ANTIGEN RECEPTORS AND CELLS EXPRESSING THE SAME

To provide chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor, a G-protein coupled receptor family C group 5 member D (GPRC5D), and immunoresponsive cells comprising such CARs, for treatment of cancer.SOLUTION: A chimeric antigen receptor (CAR) comprises an extra...

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Hauptverfasser:	BRADLEY J HEIDRICH, LI YINGZHE, LEE JEONG, SINGH SANJAYA, SATHYA VENKATARAMANI, RAJKUMAR GANESAN, FRANCOIS GAUDET, RICARDO ATTAR, CARMEN BACA JONES
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor, a G-protein coupled receptor family C group 5 member D (GPRC5D), and immunoresponsive cells comprising such CARs, for treatment of cancer.SOLUTION: A chimeric antigen receptor (CAR) comprises an extracellular antigen-binding domain, a transmembrane domain and an intracellular signaling domain, wherein the extracellular antigen-binding domain consists of a specific sequence and targets a G-protein coupled receptor family C group 5 member D (GPRC5D).SELECTED DRAWING: None 【課題】癌の治療のために、Ｇタンパク質共役型受容体と、Ｇタンパク質共役型受容体ファミリーＣグループ５メンバーＤ（ＧＰＲＣ５Ｄ）と、かかるＣＡＲを含む免疫応答性細胞と、を特異的に標的とする、キメラ抗原受容体（ＣＡＲ）を提供する。【解決手段】細胞外抗原結合ドメイン、膜貫通ドメイン、及び、細胞内シグナル伝達ドメインを含む、キメラ抗原受容体（ＣＡＲ）であって、細胞外抗原結合ドメインが、特定の配列を有し、Ｇタンパク質共役型受容体ファミリーＣグループ５メンバーＤ（ＧＰＲＣ５Ｄ）を標的とする、キメラ抗原受容体（ＣＡＲ）を提供する。【選択図】なし