TRICYCLO-DNA NUCLEOSIDE PRECURSORS AND PROCESSES FOR PREPARING THE SAME

TRICYCLO-DNA NUCLEOSIDE PRECURSORS AND PROCESSES FOR PREPARING THE SAME

To provide tricyclo-DNA nucleoside precursors and processes for preparing the same.SOLUTION: The present invention relates to a process for preparing tc-DNA nucleoside precursors, the resulting tc-DNA nucleosides, and oligonucleotides comprising such tc-DNA nucleosides. In an embodiment of the inven...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RETO BERTOLINI, BRANISLAV DUGOVIC
Format: Patent
Sprache:eng ; jpn
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:To provide tricyclo-DNA nucleoside precursors and processes for preparing the same.SOLUTION: The present invention relates to a process for preparing tc-DNA nucleoside precursors, the resulting tc-DNA nucleosides, and oligonucleotides comprising such tc-DNA nucleosides. In an embodiment of the invention, the process includes use of a carbene precursor. In an embodiment, the invention includes processes for preparing a tc-DNA nucleoside precursor of Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) or Formula (VI).SELECTED DRAWING: None 【課題】トリシクロ－ＤＮＡヌクレオシド前駆体およびそれを調製するためのプロセスを提供すること。【解決手段】本発明は、ｔｃ－ＤＮＡヌクレオシド前駆体を調製するためのプロセス、得られるｔｃ－ＤＮＡヌクレオシド、およびそのようなｔｃ－ＤＮＡヌクレオシドを含むオリゴヌクレオチドに関する。本発明の実施形態では、前記プロセスは、カルベン前駆体の使用を含む。一つの実施形態では、本発明は、式（Ｉ）、式（ＩＩ）、式（ＩＩＩ）、式（ＩＶ）、式（Ｖ）または式（ＶＩ）のｔｃ－ＤＮＡヌクレオシド前駆体を調製するためのプロセスを含む。TIFF2023129728000018.tif49119【選択図】なし