SAPOSIN C PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CANCER

To provide pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.SOLUTION: A composition comprises: a polypeptide comprising a specific amino acid sequence with zero to four amino acid insertions, substitutions or deletions; a phosphatid...

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Bibliographische Detailangaben
Hauptverfasser:	ELLEN K MONSON, CHARLES A CRUZE III, RAY TAKIGIKU, JOSEPH W WYSE, WEI XIAOCHEN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide pharmaceutical compositions containing saposin C and phosphatidylserine that are useful for treating various cancers.SOLUTION: A composition comprises: a polypeptide comprising a specific amino acid sequence with zero to four amino acid insertions, substitutions or deletions; a phosphatidylserine lipid; a buffer having a pH of 5.0 to 8.0; trehalose of 1.5 to 9 wt.%; t-butyl alcohol of 0 to 35%; and water. The polypeptide is at a concentration of 0.4 to 5.0 mg/ml, and the molar ratio of the phosphatidylserine lipid to the polypeptide is in the range from 8:1 to 20:1.SELECTED DRAWING: Figure 19 【課題】様々な癌を治療するのに有用な、サポシンCおよびホスファチジルセリンを含む薬学的組成物を提供する。【解決手段】0～4個のアミノ酸挿入、置換、または欠失を有する特定のアミノ酸配列を含む、ポリペプチド;ホスファチジルセリン脂質;pH5.0～8.0の緩衝液;1.5～9重量%のトレハロース;0～35%のt-ブチルアルコール;および水を含む組成物であって、ここで、該ポリペプチドの濃度が0.4～5.0mg/mlであり、該ホスファチジルセリン脂質と該ポリペプチドとのモル比が8:1～20:1の範囲である、組成物とする。【選択図】図１９