FUSION PROTEINS FOR SELECTIVELY DEPLETING ANTIGEN-SPECIFIC ANTIBODIES

To provide means for selectively depleting target antigen-specific antibodies from the body.SOLUTION: The present disclosure includes a fusion protein, called a "Seldeg", including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at ne...

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Bibliographische Detailangaben
Hauptverfasser:	VENKATA SIVA CHARAN DEVANABOYINA, RAIMUND JOHANNES OBER, ELIZABETH SALLY WARD OBER
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide means for selectively depleting target antigen-specific antibodies from the body.SOLUTION: The present disclosure includes a fusion protein, called a "Seldeg", including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at near-neutral pH, and an antigen component fused directly or indirectly to the targeting component. The antigen component is configured to specifically bind a target antigen-specific antibody. The present disclosure also includes a method of depleting a target antigen-specific antibody from a patient by administering to the patient a Seldeg having an antigen component configured to specifically bind the target antigen-specific antibody.SELECTED DRAWING: Figure 1 【課題】体から標的抗原特異的抗体を選択的に枯渇させる手段を提供する。【解決手段】本開示は、中性近辺のｐＨで細胞表面受容体又は他の細胞表面分子に特異的に結合する標的成分及び標的成分と直接又は間接的に融合した抗原成分を含む"Ｓｅｌｄｅｇ"と呼ばれる融合タンパク質を含む。前記抗原成分は標的抗原特異的抗体に特異的に結合するように構成される。本開示は、前記標的抗原特異的抗体に特異的に結合するように構成された抗原成分を有するＳｅｌｄｅｇを患者に投与することによって、患者から標的抗原特異的抗体を枯渇させる方法も含む。【選択図】図１