BENZOTHIAZOL COMPOUNDS AND METHODS OF USING THE SAME FOR TREATING NEURODEGENERATIVE DISORDERS

To provide a compound having c-abl kinase inhibitory activity, and a method useful to treat or prevent neurodegenerative diseases comprising administering the compound.SOLUTION: The present disclosure provides a compound represented by the formula (I) in the figure or a pharmaceutically acceptable s...

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Bibliographische Detailangaben
Hauptverfasser:	FAN MINGZHU, KIM MI-SUN, JUNG GYOOSEUNG, LIM KEONSEUNG, KIM HYONAM, JO SUYEON, LI WANJUN, LEE JINHWA, PARK A YEONG, YANG HEEKYOUNG, LIM SEUNG MOOK, LEE MINWOO, LEE GWIBIN, KIM JAE EUN, KIM HYEON JUNG
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	To provide a compound having c-abl kinase inhibitory activity, and a method useful to treat or prevent neurodegenerative diseases comprising administering the compound.SOLUTION: The present disclosure provides a compound represented by the formula (I) in the figure or a pharmaceutically acceptable salt thereof. (In the formula, R1 is cyclopropyl, cyclobutyl, or the like; R2 and R3 are H, halo, alkyl, alkoxy, or the like; and R4 is aryl, heteroaryl, cycloalkyl, or the like.)SELECTED DRAWING: None 【課題】ｃ－ａｂｌキナーゼ阻害活性を有する化合物、および該化合物を投与することを含む、神経変性疾患を治療し又は予防するのに有用な方法を提供する。【解決手段】下式（Ｉ）で示される化合物又はその薬学的に許容し得る塩を提供する。TIFF2023109868000065.tif36165（Ｒ１：シクロプロピル、シクロブチルなど。Ｒ２、Ｒ３：Ｈ、ハロ、アルキル、アルコキシなど。Ｒ４：アリール、ヘテロアリール、シクロアルキルなど。）【選択図】なし