IMPROVED HEMATOPOIETIC STEM AND PROGENITOR CELL THERAPY

To provide improved hematopoietic stem and progenitor cell therapy.SOLUTION: The invention provides an improved method for cell therapy. In particular, the invention provides therapeutic compositions of hematopoietic stem and/or progenitor cells having improved engraftment and homing properties, as...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	JOHN MENDLEIN, DANIEL SHOEMAKER, CAROLINE DESPONTS, DAVID L ROBBINS, PAUL GRAYSON, PRATIK MULTANI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To provide improved hematopoietic stem and progenitor cell therapy.SOLUTION: The invention provides an improved method for cell therapy. In particular, the invention provides therapeutic compositions of hematopoietic stem and/or progenitor cells having improved engraftment and homing properties, as well as methods for preparing the therapeutic compositions. The invention further provides a method for improving the efficacy of hematopoietic stem and progenitor cell transplantation comprising a step of transplanting the therapeutic composition to a subject in need of hematopoietic system reconstitution. In one embodiment, the invention provides a therapeutic composition comprising a cell population comprising at least about one million human hematopoietic stem or progenitor cells.SELECTED DRAWING: None 【課題】改善された造血幹細胞および前駆細胞療法を提供すること。【解決手段】本発明は、細胞療法の改善法を提供する。特に、本発明は、生着特性およびホーミング特性が改善、改変された造血幹細胞および／または前駆細胞による治療用組成物、ならびに治療用組成物を作製する方法を提供する。本発明は、造血幹細胞移植および前駆細胞移植の有効性を改善する方法であって、造血系再構築を必要とする被験体に治療用組成物を移植するステップを包含する方法もさらに提供する。一実施形態において、本発明は、少なくとも約百万個のヒト造血幹細胞または前駆細胞を含む細胞集団を含む治療用組成物を提供する。【選択図】なし