ANTIBODIES USEFUL IN CANCER DIAGNOSIS

To provide antibodies directed against an epitope located within the C-terminal portion of CLDN6 which are useful for diagnosing cancer and/or determining whether cancer cells express CLDN6.SOLUTION: The present invention provides an antibody or an antigen-binding fragment thereof, which binds to a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	TUERECI OEZLEM, RITA MITNACHT-KRAUS, STEFAN WOELL, SAHIN UGUR, KORDEN WALTER
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide antibodies directed against an epitope located within the C-terminal portion of CLDN6 which are useful for diagnosing cancer and/or determining whether cancer cells express CLDN6.SOLUTION: The present invention provides an antibody or an antigen-binding fragment thereof, which binds to a peptide having a specific amino acid sequence, and/or to claudin 6 (CLDN6), wherein the antibody or antigen-binding fragment thereof binds to CLDN6 by binding at least to an epitope within CLDN6 having a specific amino acid sequence.SELECTED DRAWING: None 【課題】癌を診断するおよび／または癌細胞がＣＬＤＮ６を発現するか否かを決定するのに有用な、ＣＬＤＮ６のＣ末端部分内に位置するエピトープに対する抗体を提供する。【解決手段】特定のアミノ酸配列を有するペプチド、および／またはクローディン６（ＣＬＤＮ６）であって、抗体もしくはその抗原結合フラグメントは、少なくとも特定のアミノ酸配列を有するＣＬＤＮ６内のエピトープに結合することによってＣＬＤＮ６に結合する、クローディン６（ＣＬＤＮ６）、に結合する抗体またはその抗原結合フラグメントを提供する。【選択図】なし