UNIVERSAL ABT COMPOUNDS AND USES THEREOF

To provide compounds and methods useful for recruiting antibodies useful for treating various diseases including cancer to cancer cells.SOLUTION: Provided is a compound comprising a universal antibody binding moiety and a targeting moiety; in some embodiments, provided is a drug comprising an antibo...

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Bibliographische Detailangaben
Hauptverfasser: DAVID ADAM SPIEGEL, MATTHEW ERNEST WELSCH
Format: Patent
Sprache:eng ; jpn
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Beschreibung
Zusammenfassung:To provide compounds and methods useful for recruiting antibodies useful for treating various diseases including cancer to cancer cells.SOLUTION: Provided is a compound comprising a universal antibody binding moiety and a targeting moiety; in some embodiments, provided is a drug comprising an antibody binding moiety, a target binding moiety, and optionally a linker moiety, the antibody binding moiety being capable of binding two or more antibodies having different Fab regions; and moreover, in some embodiments, provided is a drug, in which an antibody binding moiety, e.g., a universal antibody binding moiety binds to the Fc region of an antibody.SELECTED DRAWING: None 【課題】がんを含む様々な疾患を治療するのに有用な抗体をがん細胞に動員するのに有用な化合物及び方法を提供する。【解決手段】普遍的な抗体結合部分及び標的部分を含む化合物であって、いくつかの実施形態では、薬剤であって、抗体結合部分、標的結合部分、及び任意にリンカー部分、を含み、該抗体結合部分は、異なるFab領域を有する2つ以上の抗体に結合し得る、該薬剤、さらにいくつかの実施形態では、抗体結合部分、例えば、普遍的な抗体結合部分は、抗体のFc領域に結合する薬剤である。【選択図】なし